On-Demand Webinars: Forensic Toxicology and Clinical Research

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Forensics Toxicology

High Resolution Orbitrap MS for Detecting New Psychoactive Drugs Top of Form
The emergence of novel psychoactive substances (NPS) is an ongoing challenge for forensic toxicologists. Different analogs are continuously introduced in the market to circumvent legislation and to enhance their pharmacological activity.
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Webinar Series: Overcoming Challenges in Sports Doping Analysis
Antidoping testing programs seek to preserve what is intrinsically valuable about sport: playing true. Authorities depend on accurate analysis using chromatography and mass spectrometry (MS) for detecting a growing list of prohibited substances and practices.In this two part webinar series Dr. Alessandro Casilli, Brazilian Laboratory for Doping Control, discusses the use of state-of-the-art Orbitrap HRAM-MS and IRMS in the fight against sports doping. You will learn how this important laboratory is able to provide the highest quality results and detect the use of prohibited substances in sporting events.
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Fast Forensic Hair Analysis for Drugs of Abuse Using DART Ionization and Orbitrap HRAM
Hair is a very interesting matrix for forensic investigations: it can be collected less invasively than blood or urine and be stored easily. Not only can hair evidence be used for microscopic comparisons or provide a source of DNA, it also contains traces of used substances such as drugs of abuse, pharmaceuticals and toxicants. In addition, these compounds can be detected with a longer detection window compared to blood and urine. Where drugs of abuse in forensic investigations are conventionally detected using LC- or GC-MS(/MS) methods, recent developments in direct and ambient mass spectrometry have opened up the forensic field to exciting new possibilities. Over the last decade several ambient ionization techniques have been developed, which allow analysis of samples with (almost) no sample preparation. One of these ambient ionization techniques, Direct Analysis in Real Time (DART), has been explored for the analysis of intact locks of hair. The use of DART ionization results in fast analysis without the use of extensive sample preparation or matrix application.  
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Comprehensive Anti-doping Detection Using the Q Exactive Orbitrap MS for Equine Urine
In this presentation, Dr. Scott Stanley from the School of Veterinary Medicine at the University of California, Davis discusses the ever changing and dynamic field of science of equine anti-doping. The constant introduction of new drugs and biopharmaceuticals present challenges to the integrity of sports. Anti-doping programs are continually falling under fire due to allegations of perceived doping by athletes with drugs that are rumored to be undetectable by the current testing schemes which in some cases offer limited drug coverage. He will also detail the advancements of modern mass spectrometry, specifically, the Orbitrap MS that have enabled anti-doping laboratories to significantly expand the drug coverage for both human and equine athletes.
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How to Streamline Sample Preparation for Equine Drug Screening Using LC-MS
In this presentation, Joe Di Bussolo from Thermo Fisher Scientific and Carisa Dixon Tate from PETRL discuss how screening blood samples from race horses for prohibited drugs requires validated methods and instrumentation that maximize sensitivity and selectivity while minimizing sample handling.
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Identifying Unknowns with High Resolution Accurate Mass MS in Toxicology Webinar
Despite the increasing use of modern high resolution mass spectrometers, toxicological analysis is hindered by an inability to identify detected compounds effectively. We will present an advanced computational and database framework leading to the much anticipated increase in coverage of toxicologically relevant compounds and their transformation products, taking into account all the important experimental and calculated information necessary for efficient and reliable identifications. Those methods are exploiting combination of library searching methods, both spectral (mzCloud) and structural (PubChem, ChemSpider), with computational techniques like quantum chemical methods, precursor ion fingerprinting, fragment ion search and others.
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An Intelligence Led Approach to the Detection of DoA and Novel Psychoactive Substances
New Psychoactive Substances (NPS) represent an increasing and ever evolving threat to public health. Traditional analytical approaches to drugs of abuse testing are unable to respond quickly enough to be able to keep up to date with the continually changing NPS situation and are therefore unsuitable for this purpose.  The availability of drug intelligence often combined with drug seizures provides the starting point for a new approach to drugs of abuse testing using HRAM.  Screening processes continually evolve as new compounds emerge and can be further refined using data from in vitro metabolism and/or positive findings.
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Exhaled Breath Analysis Becomes Easier for more Reliable Drugs of Abuse Testing
Exhaled breath is an attractive biomatrix for forensic toxicological investigations. Recent findings have demonstrated the potential of using also for nonvolatile components. Human exhaled breath contains aerosol particles in sub micrometer size that are formed from the airway lining fluid. The particles contain typical proteins and lipids from this fluid. A very simple collection device has been constructed to capture the particles in a sampling procedure that is truly noninvasive in nature and only takes 2-3 min to perform. In this webinar Dr Olaf Beck, Lab Director at the Kalorinska Institute, will discuss how this specimen from exhaled breath can be used for analyzing drugs of abuse using the QQQ LC-MS/MS technique.
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Advances in Forensic Analyses: When to Use GC-MS/MS, LC-MS/MS, and high-resolution accurate-mass spectrometry (HRAM)
What’s the best tool to use? With the availability of GC-MS, LC-MS/MS, and HRMS to perform toxicology, seized drugs analysis or arson investigations forensic scientists may be left in the dark on the clear benefits of the different technologies. Choosing the best one ultimately depends on the application.
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Advances, Benefits and Challenges of Oral Fluid Testing in Forensic Toxicology
Advances in analytical technology have made oral fluid testing more of a reality in forensic toxicology. Improvements in sample preparation methods and innovations such as high resolution accurate mass spectrometry (HRAM-MS) provide the necessary sensitivity for identifying cannabinoids, THC, stimulants, and a wide variety of drugs of abuse in oral fluid.
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Future of designer drug analysis: Where are we going with HRAM?   View webinar
Novel Psychoactive Substances: Challenges and Choices in Forensic Toxicology View webinar
Forensic Toxicology Lab of the Future – Close your uncertainty gap with High Resolution Mass Spectrometry View webinar
Comprehensive Anti-doping Detection using the Q Exactive Orbitrap Mass Spectrometer for Equine Urine Analysis View webinar
Exploring the Q Exactive Orbitrap Technology for Comprehensive Urine Drug Screening for Research and Forensic Use View webinar
Forensic Analysis: FTIR, Raman and GC-IR Within Minutes  
FTIR and Raman spectroscopy are both SWGDRUG Category A techniques that can be used by forensic scientists to quickly identify unknown materials and confidently give expert testimony in court. They are also very useful for addressing SWGMAT needs.The new Nicolet iS50 FTIR with a built-in diamond ATR and sample compartment Raman module, combines these two techniques in a single compact workstation. Get answers in less than 30 seconds and switch to your next analysis method with a push of a button. The system can also be expanded with a new GC-IR interface to provide unprecedented ease of use for drug isomer identification.
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Forensic Applications of Microspectroscopy  
FTIR and Raman microscopy produce fast, minimally destructive analysis with diagnostic chemical identification results. All types of physical evidence particles ranging in size from 10 microns to 500 microns are candidates for analysis with these techniques.
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Seized Drug Analysis Using FTIR with Mixture Searching  FTIR spectroscopy is a SWGDRUG Category A technique for illicit drug identification. However, it is underutilized in many forensic laboratories. This is largely due to the ambiguous results it can provide when analyzing seized drugs that are mixtures. These results are difficult for the forensic scientist to confidently support when giving expert testimony. View webinar
Forensic applications of microspectroscopy – tools for confident sampling and data reporting
This webinar demonstrates how new tools like enhanced low-pressure diamond cells and micro-ATR produce excellent results on samples important in Forensic investigations. Topics will include: Sampling approaches to improve performance and data reliability for FTIR microscopy in forensic laboratories Learning special tools for simplifying micro-FTIR including: diamond cells, micro-ATR, preparation tips, and creating data bases Combining FT-IR with an optical microscope to extend analysis power to many small and complex forensic samples such as fibers, paint chips, inks, and other physical evidence How IR microscopy can produce excellent results on fibers, paints, inks, and energetic materials samples. Using Raman microscopy for some samples to get around certain spatial resolution and sample preparation problems, while supplying equally diagnostic results Software tools applicable to both techniques for identifying unknowns and mixtures will also be discussed  
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Illicit tablet analysis using Raman spectroscopy
Raman spectroscopy can be used for the analysis of prescription, counterfeit, and designer drug tablets in just minutes with little to no sample preparation. As part of the presentation we will make our debut presentation of the new Law Enforcement and Security (LEnS) spectral library which contains over 8300 unique spectra. Also featured will be the use of our multicomponent spectral search software, OMNIC Specta, for simplifying the analysis of complex tablet data.  
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Clinical Research

Global Protein Profiling Using pSMART on the Q Exactive MS
The goal of translational proteomics is to identify putative protein markers that may define a biological condition and incorporate the protein-based markers into routine, quantitative assays. This requires an integrated analytical approach designed to identify and verify peptide surrogates in a small cohort as well as determine differential expression ratios across biological groups. Experimental methods incorporate well-characterized sample preparation, separation, and liquid chromatography coupled to mass spectrometry (LC-MS) methods which collectively facilitate global qualitative and quantitative determinations across all samples. 
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Data-Independent Analysis and Targeted MS/MS Quantification of Biomarkers
Clinical research applications of proteomics increasingly rely on MS-based approaches. Biomarker discovery, development, verification, validation, and quantification are all accessed using these approaches. Although different data collection modes exist for biomarker assessment, researchers are focusing on the emerging DIA mode in Combining Data-Independent Analysis (DIA) for Broad-Scale Phenotyping and Targeted Tandem Mass Spectrometry Quantification of Specific Biomarkers.
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Implementation of Multi-Channel LC-MS for Clinical Research Analyses
One of the major challenges for adopting LC-MS technology is the limited throughput and automation compared to typical clinical chemistry instruments. This is an important issue because in the areas of toxicology, endocrinology, and therapeutic drug monitoring there are some important applications for which there are no commercial solutions. Laboratory developed tests using LC-MS and other technologies are needed to bridge this gap. In this webinar we discuss the opportunities and challenges for LC-MS in the clinical research laboratory, and describe ways that TurboFlow technology and multi-channel LC-MS systems increase efficiency and throughput.
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Therapeutic Drug Monitoring Research using High Resolution Mass Spectrometry
Therapeutic drug monitoring research (TDM) is important due to its impact on treatments and disease management. TDM research of antidepressants is critical to ensure compliance and to rule out pharmacokinetic abnormalities such as rapid metabolizer genotype or drug interactions.
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Translational Proteomics: From One-By-One to All-In-One Clinical Assays
Mass spectrometry plays a key role in the translational proteomics pipeline: whereas continuous improvements in technologies at the discovery side increase qualitative and quantitative coverage of the entire proteoform diversity, ongoing optimization of methodologies at the clinical diagnostic site improve analytical quality and standardization. Integrating both ends would streamline the discovery of new biomarkers by increased analytical quality, and revolutionize clinical diagnostic assays by adoption of multi-protein strategies, including isoforms and post-translational modifications.
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Combining Proteomics Research with Small Molecule Assays in a Clinical Proteomics Platform
Proteomics utilizes a comprehensive set of technologies to detect, quantify and characterize proteins to assess normal biology and perturbations that cause diseases. Research clinicians wish to access  leverage the analytical power of proteomics (and LCMS in general) to better understand disease and potentially provide better therapeutic solutions in medical care, but are generally not  formally trained in LCMS technology.
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From Biology to Routine Measurement: New Methods and Workflows for Translational Clinical Research
In this webinar Dr Mary F. Lopez will discuss complete LC-MS workflows that integrate data from discovery and targeted quantification experiments to streamline and simplify translational clinical research.
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High-Coverage High-Throughput Characterization of Breast Cancer Cell Line Proteomes Using 10-Plexed TMT on an Orbitrap Fusion
Download this Wiley webinar to learn about the use of TMT-10 reagents and the Thermo Scientific™ Orbitrap™ Fusion™ mass spectrometer for quantitative proteomics on 32 breast cancer cell lines using a synchronous precursor selection supported MS3 method.
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Turbulent Flow LC and MS: Research into Potential Applications for Clinical Chemistry and Therapeutic Drug Monitoring
With advances in fast chromatography techniques, and highly sensitive and selective detection methods such as mass spectrometry, high-throughput bioanalytical methods can now be easily developed. The bottleneck of the analytical process then becomes the sample preparation, which it is now realized is crucial to the robust operation of the analytical system, especially for quantitative assays. Turbulent flow liquid chromatography was developed in the late 1990s, and combines ‘size exclusion’ and traditional stationary phase column chemistry to separate macromolecules, such as proteins, from smaller molecules and analytes of interest in biological fluids.
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Biomarker Discovery: Translating Proteomics into Clinical Diagnostics View webinar
Applications of LC-MS: Development and Research of a Highly Sensitive LC-MS Research Method for Quantification of a Cholesterol Protein in Plasma View webinar
Label-free cellular analysis with Raman imaging
45 minutes
Presenter: Matt Meyer, Ph.D, Research Scientist, Thermo Fisher Scientific
Raman imaging for life science research offers unique analytical capabilities for cell biology, enabling label-free characterization of biological systems with sub-micron spatial resolution. The ability to visualize living samples spatially and temporally to non-invasively understand molecular composition and dynamics has made Raman imaging a promising tool for cellular analysis. The DXRxi Raman imaging microscope allows the user to study living specimens through chemical imaging of components in their native environment. We will illustrate how this is an effective technique for live human cells, bacteria cells and model organisms. Among the topics to be discussed in this webinar: Collection of Raman images from live cells showing the distribution of biological components including nucleic acids, cytochrome c, lipids and proteins. Examples of how Raman imaging can be used for chemical analysis of live cells, bacteria cells and model organisms.  
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Characterization of wound healing progress with Raman spectroscopy
Guest presenter: Doctoral candidate, Rishabh Jain of the Chemical Engineering Department at the University of Wisconsin-Madison
25 minutes
Biological tissues pose an analytical challenge because they are compositionally complex and the information they provide can be difficult to objectively uncover. Raman spectroscopy offers an objective technique for characterization, however information from Raman spectra can be hard to reliably extract. We will explore how Raman microscopy can be utilized as a simple, non-invasive method to biochemically characterize healing wounds, particularly when coupled with multivariate spectral analysis to accurately identify different phases of the healing of wounds with time in clinical research. Considering wounds as a model biological surface, the webinar will address: Challenges associated with collection of Raman spectra from a biological tissue or surface The potential of Raman spectroscopy for real-time, in situ biochemical characterization of biological tissues for clinical research   
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Supplemental detection and classification methods of glaucoma disease states using Raman spectroscopy
Guest presenter: Dr. Chenxu Yu of the Department of Agricultural and Biosystems Engineering at Iowa State University
25 minutes
This webinar discusses the potential of using Raman spectroscopy as a supplemental detection tool of glaucomatous changes in retinal tissues in vitro. Raman spectroscopic imaging was conducted on normal retinal tissues and retinal tissues with a variety of symptoms related to glaucoma. This webinar will address the use of Raman spectroscopy in clinical research, screening for the detection and characterization of early stage glaucoma disease. This webinar discusses: Collection of Raman spectral from normal retinal tissue, as well as tissue from retinas exhibiting glaucoma, elevated intraocular pressure, and compressive optic neuropathy Spectroscopic discrimination between each class of tissues, and the potential to harness these differences for detection and even prevention of disease  
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