Webinar: Liquid Extraction Surface Analysis (LESA) mass spectrometry of intact proteins– Live webinar May 7, 2020

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Date/Time
Date(s) - 07/05/2020
5:00 pm - 5:30 pm

Categories


In this webinar, Dr. Cooper will discuss a novel workflow for spatial profiling of intact proteins on tissue slices utilizing native LESA MS to identify larger proteins (>47 kDa) than previous research, as well detecting and characterizing protein complexes with molecular weights ca. 103 kDa, demonstrating the softness of the ionization and transmission of protein complexes through FAIMS. Higher order MSn is performed to dissociate the complexes into subgroups, and sequence subgroups using multiple dissociation techniques. Combining FAIMS with LESA MS has enabled detection of hundreds of proteins in human liver sections.

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What you will learn:

  • Improve data quality using differential ion mobility
  • Increase proteome profiling using FAIMS-LESA-Orbitrap workflow
  • Succeed at quantitative proteomic workflows for rapid top-down characterization

Who should attend:
Researchers, Lab technicians and Directors including:

  • Director, PIs & Managers of mass spectrometry labs
  • Director, PIs & Managers using proteomics to investigate fundamental biology
  • Users interested in applying FAIMS to improve TMT, crosslinking, or proteomic workflows
  • Directors, PIs & Managers in Pharma/Biopharma evaluating drug-protein binding

 

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