Application note: Mass Spectrometric Analysis of Intact Complex Biotherapeutics

For the analysis of more complex molecules, such as antibody-drug conjugates, native mass spectrometry is beneficial to characterize the sample and obtain the accurate drug-to-antibody ratio.
This new white paper explores how LC/MS analysis of intact therapeutic antibodies can be performed with high accuracy and sensitivity down to sub-nanogram levels for molecular weight confirmation and assessment of isoform pattern.

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New application on intact and native mass spectrometry: Comprehensive ADC characterization
This application demonstrates complete characterization of a lysine-linked antibody drug conjugate by native LC/MS & peptide mapping.

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