Introducing the UNSTOPPABLE Thermo Scientific ISQ 7000 single quadrupole GC-MS and TSQ 9000 triple quadrupole GC-MS/MS systems. These truly scalable platforms power your inner superhero with UNSTOPPABLE sensitivity, uptime, and ease of use. Now you can revolutionize your analyses for a range of sample types, all while increasing throughput and reducing cost-per-sample.

  • Ultimate sensitivity with Advanced Electron Ionization source
  • Routine ease-of- use from method development to daily operation
  • Extended uptime with inherent robustness and NeverVent™ technology
  • True scalability to face evolving regulatory requirements

Innovative MS technology future-proofs GC-MS investment


Innovative technologies applied to the Thermo Scientific ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS systems work together to deliver UNSTOPPABLE GC-MS system performance. You get best-in-class sensitivity, uptime, and ease of use, future-proofing your investment to address increasingly challenging regulatory requirements.

ExtractaBrite ion source

Boost throughput

Part of Thermo Scientific NeverVent technology, the Thermo Scientific ExtractaBrite ion source technology delivers proven rugged electron impact (EI) and chemical ionization (CI) performance. The source is removable for maintenance or switching ionization modes without breaking vacuum. In addition, by exchanging the ion source with the V-Lock source plug, GC columns can be replaced without venting.

To protect analyte integrity and maximum robustness, the ExtractaBrite ion source is comprised of highly inert material. It is also heated throughout to prevent mass analyzer contamination and to ensure matrix tolerance for high-throughput work. As a result, there is never a need to heat or clean the quadrupoles.

Advanced Electron Ionization (AEI) source

Advanced Electron Ionization (AEI) source

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The ultra-robust, ultra-sensitive Advanced Electron Ionization (AEI) source is available in dedicated ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS system configurations. Highly efficient ionization, a tightly focused ion beam, and heating throughout the source reduce mass spectrometer contamination, extend system uptime, and lower instrument detection limits to unprecedented levels. With ultra-high sensitivity, the AEI source can also help reduce sample concentration steps and consequent matrix pressure on the analytical system.



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Part of the TSQ 9000 triple quadrupole GC-MS/MS system, Enhanced Velocity Optics Collision Cell (EvoCell) technology boosts sample throughput with very high selected-reaction-monitoring (SRM) transition speeds, providing enhanced precision and sensitivity for even the most complex methods. Timed-SRM (t-SRM) software automates optimization of SRM scheduling.

EvoCell technology can be used to increase the scope of SRM methods to fit a wider range of compounds and matrices, increase sample throughput by compressing GC time, or increase method resistance to interferences, matrix effects, and retention time shifts.

NeverVent technology

Patented Thermo Scientific NeverVent technology delivers UNSTOPPABLE GC-MS uptime. Used with the ExtractaBrite ion source, the vacuum probe interlock (VPI) and the V-Lock source plug isolate the vacuum region of the mass spectrometer from the gas chromatograph, allowing routine source cleaning, and ion source and column changing, without venting.

Dual filament

The dual filament design extends instrument uptime. Both filaments produce similar analytical performance so you can switch from one to the other without impacting analytical performance. To simplify operation, the dual filament assembly is used for both EI and CI modes.

GC-MS transferline


Independently heated zones for transfer line, ion source, and ion optics help ensure that the system stays cleaner for a longer period of time.

The optimized GC-MS transferline evenly distributes heat across the length of the analytical column, ensuring that there are no hot or cold spots, which in turn delivers Gaussian peak shapes, even for high boiling point compounds.

Ion source probes

Direct insertion probe

Optional ion source probes enable you to perform real-time MS and MS/MS experiments on solid samples with easy switching between EI and CI modes. Like the ExtractaBrite ion source, the probes can be removed without venting.

Available ion source probes:

Direct Insertion Probe (DIP) for rapid analysis of components in solid matrices.

Direct Exposure Probe (DEP) for rapid molecular weight confirmation of solids dissolved or suspended in liquid solvents.

UNSTOPPABLE scalability

UNSTOPPABLE scalability

 In an evolving world, it’s important to be prepared for the future. The fully scalable ISQ 7000 GC-MS system provides a upgrade path from basic to advanced configurations, allowing you to add capability if you need it. With five performance and price levels, and field-upgrade options, you can invest in fit-for-purpose solutions at the right cost and still expand your analytical capability in the future.


Pressure to increase productivity, and the growing list of compounds that laboratories must quantify and screen, necessitate workflow-driven software. Intuitive Thermo Scientific Chromeleon Chromatography Data System (CDS) software is available to streamline quantitative workflows. Download ready-to-use Thermo Scientific eWorkflows from the Thermo Scientific AppsLab Library to jump-start method development. For U.S. EPA-based environmental applications, the Environmental Analysis Extension Pack provides a set of GC-MS e-workflow and reporting templates.

  1. Fixed Calibration, Check Standards, QC Samples, Unknowns
  2. Tune Check, Calibration Curve, QC Samples
  3. Fixed Calibration, Check Standards, Injections for computing Minimum Detection Level (MDL)
  4. Fixed Calibration, Check Standards, Injections for performing method validation



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